CALL FOR PAPERS Comparative Genomics New Zealand Ginger mouse: novel model that associates the tyrp1 pigmentation gene locus with regulation of lean body mass
نویسندگان
چکیده
Cécile E. Duchesnes, Jürgen K. Naggert, Michele A. Tatnell, Nikki Beckman, Rebecca N. Marnane, Jessica A. Rodrigues, Angela Halim, Beau Pontré, Alistair W. Stewart, George L. Wolff, Robert Elliott, and Kathleen G. Mountjoy Departments of Physiology, Molecular Medicine and Pathology, Paediatrics, and Biomedical Imaging, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, New Zealand; The Jackson Laboratory, Bar Harbor, Maine; and Division of Biomedical Toxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas
منابع مشابه
CALL FOR PAPERS Comparative Genomics Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes
Wilson MD, Cheung J, Martindale DW, Scherer SW, Koop BF. Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes. Physiol Genomics 27: 201–218, 2006. First published August 22, 2006; doi:10.1152/physiolgenomics.00284.2005.—Many aspects of the immune system are controlled by homologous cell surface...
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Background Genomic imprinting is a heritable and developmentally essential phenomenon by which gene expression occurs in an allele-specific manner1. While the imprinted alleles are primarily silenced by DNA methylation, it remains largely unknown how methylation is targeted to imprinting control region (ICR), also called differentially methylated region (DMR), and maintained. Here we show that ...
متن کاملCharacterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1.
New Zealand obese (NZO) mice present a metabolic syndrome of obesity, insulin resistance, and diabetes. To identify chromosomal segments associated with these traits, we intercrossed NZO mice with the lean and diabetes-resistant C57BL/6J (B6) strain. Obesity and hyperglycemia in the (NZO x B6)F2 intercross population were predominantly due to a broad quantitative trait locus (QTL) on chromosome...
متن کاملComplex interactions of Tyrp1 in the eye
PURPOSE To use a systems genetics approach to construct and analyze co-expression networks that are causally linked to mutations in a key pigementation gene, tyrosinase-related protein 1 (Tyrp1), that is associated both with oculocutaneous albinism type 3 (OCA3) in humans and with glaucoma in mice. METHODS Gene expression patterns were measured in whole eyes of a large family of BXD recombina...
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